ABACAVIR – Drug Information

Therapeutic Classification: Antiretroviral Agents

Chemical Formula: C14H18N6O

Description:

Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. It can cross the blood-brain barrier.

Pharmacokinetics:

Abacavir is given orally and is rapidly absorbed with a high bioavailability of 83%. It is metabolized primarily through the enzymes alcohol dehydrogenase and glucuronyl transferase to an inactive carboxylate and glucuronide metabolites.

Mechanism of Action of Abacavir:

Abacabir is a powerful nucleoside reverse transcriptase inhibitor that inhibits viral replication. It is a guanosine analogue that is phosphorylated to carbovir triphosphate (CBV-TP). CBV-TP competes with the viral molecules and is incorporated into the viral DNA. Once CBV-TP is integrated into the viral DNA, transcription and HIV reverse transcriptase is inhibited.

Pregnancy Category:

Category C

  • Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

Dosage for Abacavir:

In the treatment of HIV-1/AIDS along with other medications. Dose in adults is 600 mg daily, as a single dose or divided into two doses. It can take with or without food.

Warning and Precautions for Abacavir:

  • Before taking this medication, tell your doctor or pharmacist if you are allergic to it. This product may contain inactive excipients, which may cause allergic reactions or other problems. Talk to your pharmacist for more details.
  • Stop taking this medication immediately if hypersensitivity reaction suspected. Never start again after suspected hypersensitivity reaction because more severe symptoms can occur within hours and may include life-threatening hypotension and sometime death.

Adverse Effect / Side Effect of Abacavir:

Hypersensitivity to Abacavir, Nausea, Vomiting, Liver Problem, Fever, Rash, Anorexia, Headache, Diarrhoea, Cough, Dyspnoea, Fatigue, Malaise, Lethargy, Abdominal pain.

Other Drug Interactions:

Alcohol may cause decreased elimination of abacavir. Lactic acidosis with nucleoside analogues concomitantly. Decreased serum concentrations of methadone.

Brand Name / Trade Name Available in India:

Abmune | Abavir (300mg) | Abcavir | Abec (300mg) | Abamune (300mg) | Abec | Abamune | Abamune-L (600mg/300mg) | Virol 

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