ABATACEPT – Drug Information

Generic Name: Abatacept

Therapeutic Classification: Antirheumatics

Description:

Abatacept is a synthetic protein, prescribed for adult with moderate to severe rheumatoid arthritis including patients who have not responded to DMARDs (disease-modifying anti-rheumatic drugs), and juvenile idiopathic arthritis.

Mechanism of Action:

Abatacept is a synthetic protein, it prevents antigen-presenting cells (APCs) from delivering the co-stimulatory signal and It blocks the activity of T-cells, which causes swelling and joint damage in people with arthritis condition.

Warnings and Precautions for Abatacept:

  • Patient may develop with serious infections and tumor. Caution should be exercised in patients with history of lung, nerve diseases, cancer, Human Immunodeficiency Virus, tuberculosis, severe combined immunodeficiency syndrome, cut or open sore, diabetes, during pregnancy and breastfeeding.
  • Avoid vaccination while taking this medication.

Adverse Reactions / Side Effects of Abatacept:

Infection and cancer, headache and dizziness, upper respiratory tract infection and inflammation of nasopharynx, nausea, indigestion and severe abdominal pain, rash, red or painful skin, hives, cough, fever, tiredness, flu-like symptoms, or warm, swelling of the eyes, face, lips, tongue, or throat, back pain, high blood pressure, indigestion, heartburn, night sweats, urinary tract infection, change in the amount of urine and pain in arms and legs.

Side effects in children: Upper respiratory tract infection, inflammation of nasopharynx, headache, nausea, diarrhea, cough and abdominal pain.

Dose:

  • It is administered as an injection into the vein (IV), or as a solution for subcutaneous (under the skin) injection by a healthcare provider every 2 weeks for the first 3 doses and then every 4 weeks.
  • Dose is based on body weight and condition of the patient. Weight < 60 kg should receive 500 mg dose, weight 60-100 kg a 750 mg dose and weight >100 kg a 1000 mg dose.
  • Juvenile Idiopathic Arthritis- Pediatric patients weighing less than 75 kg: receive 10 mg/kg.

Storage Conditions:

Normally handled and stored by healthcare providers in refrigerator. Do not freeze and keep it away from light.

Trade Names / Brand Names:

International- I Orencia I

 

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