ACENOCOUMAROL – Drug Information
Generic Name : Acenocoumarol
Therapeutic Classification: Anticoagulants / Antithrombotics
Acenocoumarol is a derivative of coumarin. This medication is an anticoagulant, prescribed for thromboembolic disorders. Anticoagulants decrease the clotting ability of the blood and therefore help to prevent harmful clots from forming in the blood vessels. These medicines are sometimes called blood thinners, although they do not actually thin the blood. They also will not dissolve clots that already have formed, but they may prevent the clots from becoming larger and causing more serious problems. They are often used as treatment for certain blood vessel, heart, and lung conditions.
Mechanism of Action:
Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K.
Adverse Reactions/Side Effects of Acenocoumarol:
- Central Nervous System: Headaches, dizziness, or weakness.
- Skin: Hair loss, rash, hives and itching.
- Gastrointestinal: Loss of appetite, nausea, vomiting and diarrhea.
- Respiratory: Sudden shortness of breath.
- Liver: Liver damage.
- Potentially Fatal: Severe bleeding.
- Others: Feeling sick, unusual pain or swelling, alopecia, severe bleeding.
Warnings & Precaution for Acenocoumarol:
- Caution use in the patients with history of bleeding disorders, peptic ulcer, severe wounds, allergies, stroke, stomach infections, liver or kidney impairment, elderly, children and breastfeeding.
- Avoid alcohol consumption while taking this medication.
Contraindications for Acenocoumarol:
Pregnancy, Lactation, Children, Active Haemorrage, Severe Hypertension.
Dosage of Acenocoumarol:
Thromboembolic disorders Adult: 4-12 mg on the 1st day and 4-8 mg on the 2nd day. Maintenance: 1-8 mg daily given in a single dose at the same time every day.
Other Drug Interactions:
Potentiates hypoglycaemic agents. Bismuth carbonate and Mg reduce absorption. Cimetidine, allopurinol, diuretics and other oral anticoagulants enhance effect. vit K reverses effect. Potentially Fatal: Potentiated by NSAIDs, amiodarone, antibacterial agents eg, co-trimoxazole, cephalosporins, erythromycin, quinolone antibiotics, chloramphenicol, doxycycline, INH and neomycin. Rifampicin, barbiturates and griseofulvin diminish effect.
Trade Name/Brand Name:
Acitrom (3 mg) | Nistrom | Acitrom (4 mg) | Nistrom (2 mg) | Acitrom (3mg) | Acenomac (1mg) | Acitrom (2mg) | Nistrom (4 mg) | Acenomac (2mg) | Acitrom (4mg) | Acitrom (3 mg) | Acenomac (4mg) | Acitrom (1mg) | Acenomac (3mg) | Acitrom (1mg) | Acitrom (0.5mg)
Acebron, Acenox, Acitrom, Antitrom, Azecar, Cumarol, Coarol, Fortanol, Mini-Sintrom, Neo-Sintrom, Nistrom, Pabi-Acenocoumarol, Sinkum, Sinthrome, sintrom mitis, syncumar, Trombostop, Acenotromb