ACETAMINOPHEN (Paracetamol) – Drug Information

Generic Name : Acetaminophen

Therapeutical Classification: None-Steroidal Anti-inflamatory Drug (NSID)

Know the indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the Acetaminophen.


Acetaminophen, also known as paracetamol, is a nonsteroidal anti-inflammatory drug with potent antipyretic and analgesic actions but with very weak anti-inflammatory activity. It prescribed for headache, pain (muscle ache, backache) and fever either alone or combined with other medications.

Mechanism of Action:

Acetaminophen inhibits the synthesis of PGs by competing with arachidonic acid for the active site on the COX enzyme.

Paracetamol exhibits Analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.


It administered by orally excreted through Urine. Plasma half-life: 2.7 hours (adults); 1.5-2 hours (infants and children); 3.5 hours (neonates). Neonates, infants and children up ≤10 years excrete less glucuronide than adults. Half-life may be longer after toxic doses.



Dosage of Acetaminophen:

  • The oral dose for adults is 325 to 650 mg every 4 to 6 hours. The maximum daily dose is 4 grams.
  • Child- the recommended dose is 10 to 15 mg/kg every 4 to 6 hours.
  • It comes as a tablet and capsule to take by mouth, with or without food.

Other Drug Interactions:

Reduced absorption of cholestyramine within 1 hr of admin. Accelerated absorption with metoclopramide. Decreased effect with barbiturates, carbamazepine, hydantoins, rifampicin and sulfinpyrazone. Paracetamol may increase effect of warfarin.

Warnings and Precautions for Acetaminophen:

  • Use with caution in patients who have history of alcohol dependency, kidney or liver impairment, G6PD deficiency, elderly, children, during pregnancy and breastfeeding.
  • Acetaminophen may cause liver damage; avoid long-term use of this medication.

Side Effects / Adverse Reaction of Acetaminophen:

Nausea, vomiting, stomach pain, loss of appetite, upper stomach pain, dark urine, clay colored stool, allergic reactions, skin rash and kidney impairment.

Storage conditions of Acetaminophen:

Store tablets and solution at room temperature 15°- 30°C. Keep this medication out of the reach of children.

Trade Name / Brand Name:


Dispirin | Cemol KT| Tempros (300 mg) | Parador | Pymol (125 mg) | Paracin KT | Paracetamol | Paraz -650 | Junimol RDS (250mg) | Pimol (650 mg) | Dolo (500 mg) | Tempros (500 mg) | Tuxyne (10mg/500mg/30mg/5mg/60mg) | Calpol | P – 500 | P – 650 | Panacet | Dispar (300mg) | P -125 DT (500mg) | Parasuit | Temptal | PCM inj | Indamol 650 | Oropyrin | P – Mol – Kid | Actifast suspesion (1mg/15mg/125mg) | Cofamol | Paracetamol | Redimol | Emol (500 mg) | Calpol (60 ml) | Femol (500 mg) | Ultramol (650 mg)


Tylenol, Tylophen, Anacin Asprin free, Apra, Genapap, Feverall , Panodil, Efferalgan, Doliprane, Dafalgan, Alvedon, Panadol and Valadol


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