ACRIVASTINE and PSEUDOEPHEDRINE – Drug Information

Generic Name: Acrivastine and Pseudoephedrine

Therapeutic Classification: Antihistamines and Decongestants

Description:

Acrivastine pseudoephedrine (Semprex D) is a combination medicine used to treat runny or stuffy nose, sneezing, itching, sinus congestion, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold. It narrows blood vessels and shrinkage of the nasal mucous membranes by blocking histamine at H1 receptor sites.

Acrivastine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Pharmacology:

The mechanism of action of acrivastine is as a Histamine H1 Receptor Antagonist. It exhibits H1-antihistaminic receptor activity, which prevents histamine from binding to its receptor in target cells.

Pseudoephedrine is a decongestant; it acts on alpha-adrenergic receptors in the mucosa of the respiratory tract, producing vasoconstriction. The medication shrinks swollen nasal mucous membranes, reduces tissue hyperemia, edema, and nasal congestion. Thus resulting increases nasal airway patency.

Contraindications for Acrivastine Pseudoephedrine:

  • The Drug is contraindicated in patients with severe high blood pressure, hypersensitivity to Acrivastine or Pseudoephedrine or any component of the formulation.
  • The Drug is also contraindicated in patients who are taking or have taken monoamine oxidase (MAO) inhibitors within 14 days.

Pregnancy Category:

Category B

  • Animal studies have failed to demonstrate a risk to the fetus and appropriate studies on pregnant women are lacking.

Warnings and Precautions for Acrivastine Pseudoephedrine:

Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Many combination medicines contain antihistamines or decongestants. Taking certain products together can cause you to get too much of this medicine.

  • Use with caution in patients with cardiovascular disease (including hypertension and ischemic heart disease); contraindicated with severe disease.
  • Use with caution in patients with diabetes mellitus.
  • Use with caution in patients with history of overactive thyroid, increased eye pressure, kidney disease, stomach or bowel obstruction, peptic ulcer, urinary tract problems, prostate disease, difficulty in urinating.
  • Use with caution in patients who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding.
  • Should not be used in children under 12 years of age and people who have taken a monoamine-oxidase inhibitor antidepressant (MAOI) in the last 14 days.
  • It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
  • Avoid alcohol consumption.

Adverse Reactions / Side Effects of Acrivastine Pseudoephedrine:

  • Central Nervous System: Headache, drowsiness, dizziness, nervousness, sleeplessness, insomnia.
  • Gastrointestinal: Nausea, dry mouth, dry throat, weakness, dyspepsia.
  • Miscellaneous: Increased heart rate, increased blood pressure, increased cough, difficulty in passing urine and painful menstruation.

Dose:

Adults Dose – The recommended dose is one capsule (8mg/60mg), every 4 to 6 hours four times a day.

Other Drug Interactions with Acrivastine Pseudoephedrine:

  • Enflurane, isoflurane, or methoxyflurane may also cause some sensitization of the myocardium to the effects of sympathomimetics; caution is recommended in patients taking.
  • MAO inhibitors and beta-adrenergic agonists increase the effects of sympathomimetic amines. Concomitant use of sympathomimetic amines with MAO inhibitors can result in a hypertensive crisis.
  • Thyroid hormones – Concurrent use of may increase the effects of either these medications or pseudoephedrine; thyroid hormones enhance risk of coronary insufficiency when sympathomimetic agents are administered to patients with coronary artery disease; dosage adjustment is recommended, although problem is reduced in euthyroid patients.
  • Rauwolfia alkaloids – Concurrent use of may inhibit the action of pseudoephedrine by depleting catecholamine stores.
  • pseudoephedrine

[Note – This is not complete drug interaction list, before taking this medication with other drugs please consult with your Doctor or Pharmacist]

Storage Conditions:

Store at 15° to 25° C in a dry place and protected from light.

Trade Names / Brand Names of Acrivastine Pseudoephedrine:

International- Benadryl plus, Semprex D.

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