Acyclovir And Hydrocortisone – Drug Information

Generic Name: Acyclovir And Hydrocortisone

Therapeutic Classification: Antivirals

Overview :

Acyclovir and hydrocortisone topical combination contains antiviral and corticosteroid, is used to treat the symptoms of Herpes simplex virus infection on the lips and around the mouth (ulcerative cold sores). Although this medicine will not cure herpes simplex, it may help the sores to heal faster and relieve some of the pain and discomfort.

Cold sores are caused by the herpes virus. Acyclovir belongs to the class of medications called antivirals and works by preventing the virus from reproducing, allowing the body’s natural defenses to fight the infection. Hydrocortisone belongs to the class of medications called corticosteroids and works to decrease the swelling and redness that cold sores cause.

Contraindications for Acyclovir and Hydrocortisone :

  • Hypersensitivity
  • Side Effects / Adverse Reaction :
  • Drying or flaking of the skin
  • Burning, itching, redness, rash, swelling, soreness, or tingling at the application site
  • Change in skin colour at the application site
  • Erythema
  • Dryness
  • Pigmentation changes

Pregnancy Category :

Category B

Animal studies have failed to demonstrate a risk to the fetus and appropriate studies on pregnant women are lacking.

Warnings and Precautions for Acyclovir and Hydrocortisone :

  • This medication for topical use only on lips and around the mouth.
  • It should not be applied to eye.
  • Should not be used in children below 12 years of age.
  • Caution should be strictly followed in patients with history of poor immunity, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.
  • Do not rub the cream into the cold sore thus may resulting spread the virus to other areas around your mouth or make your cold sore worse.
  • Avoid the excess dosage.


Apply a quantity sufficient to the affected area 5 times a day for 5 days.

Storage Condition for Acyclovir and Hydrocortisone :

Store at Room Temperature 20°-25°C. Don not freeze.

Trade Name / Brand Name :

International – | Xerese |

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