Adapalene – Drug Information

Generic Name : Adapalene

Therapeutic Classification : Miscellaneous Dermatologicals

Overview :

Adapalene is in a class of medications called retinoid-like compounds. It is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. It works by stopping pimples from forming under the surface of the skin.

Mechanism of Action :

It Binds to specific retinoic-acid nuclear receptors which normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation. The exact mode of action of adapalene is unknown.

Contraindications for Adapalene :

Hypersensitivity to the drug and other excipients.

Pregnancy Category :

Category C

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

Adverse Reactions  / Side Effects of Adapalene :

Sensation of stinging and burning immediately after applying the medication, redness, dryness, itching of the skin and scaling, or worsening of acne may occur during the first 2-4 weeks of using the medication.

Warnings and Precautions for Adapalene :

  • Caution should be exercised in patients with history of eczema, sunburn, any allergy, who are taking other medications, during pregnancy and breastfeeding.
  • It is recommended to use a mild soap and lukewarm water to wash with while on this medication.
  • Avoid contact with mouth; otherwise it may be harmful.
  • Avoid applying on make-up and moisturizers.
  • Avoid exposure to sunlight or UV irradiation.
  • Waxing should not be performed on treated skin.
  • Use with caution with preparations containing sulfur, resorcinol, or salicylic acid.

Other Drug Interactions :

Increased irritation may occur with medicated or abrasive soaps, products with a pronounced drying effect and those containing alcohol or astringents.

Dosage :

It comes as a gel, a solution (liquid), and cream for topical use. A thin film of gel should be applied once a day to affected areas after washing the skin.

Storage Conditions :

Store it at room temperature (25°C), away from excess heat and moisture.

Trade Name / Brand Name :

India :

Adapen | Adgraze-AC | Aditop C | Faceclin-A | Adaferin | DEE | Rozac | Adapen | Alangel | Alene Gel | Clinred-A | Zolvee Crm | Adina | Apgel (Skin) (10gm) | Adaferin | Difra Gel | Acneril | Adlene A.D | Deriva-CMS | Apalene | Adiff | Labopene -C | Deriva-MS | Edplin | Acniriv A | Adaple Gel | Faceclin A | Adaret (15 gm) | Acnovate | Adlene-AD

International :

Differin

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